4-Chloropyridine hydrochloride → 4-[1-(4-Pyridyl)piperidin-4-yl]benzenesulphonamide

反応式

[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:12]=[CH:11][C:10]([S:13]([NH2:16])(=[O:15])=[O:14])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.Cl.Cl[C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1.C(=O)(O)[O-].[Na+]>C(O)CC(C)C>[N:22]1[CH:23]=[CH:24][C:19]([N:1]2[CH2:6][CH2:5][CH:4]([C:7]3[CH:12]=[CH:11][C:10]([S:13]([NH2:16])(=[O:14])=[O:15])=[CH:9][CH:8]=3)[CH2:3][CH2:2]2)=[CH:20][CH:21]=1

参加物

実験手順

A mixture of the product of part (iii) above (3.75 g), 4-chloropyridine hydrochloride (2.34 g), sodium bicarbonate (3.93 g) and isoamyl alcohol (60 ml) was heated under reflux for 30 hours and then evaporated. The residue was triturated with water and the mixture was filtered. The solid was washed well with water and crystallised from methanol/water to give the title compound (0.43 g), m.p. 295° (with decomp).