1,2,5-Thiadiazole-3-carboxylic acid → HCID 178429215、化合物

HRID 1762984

反応式

HRID 1762984 の反応式
[S:1]1[N:5]=[CH:4][C:3]([C:6](O)=O)=[N:2]1.[NH2:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][C:18]=1[NH2:19])[NH:15][C:14](=[O:20])[C:13]2([CH3:22])[CH3:21]>>[CH3:21][C:13]1([CH3:22])[C:12]2[C:16](=[CH:17][C:18]3[NH:19][C:6]([C:3]4[CH:4]=[N:5][S:1][N:2]=4)=[N:9][C:10]=3[CH:11]=2)[NH:15][C:14]1=[O:20]

参加物

3

反応物 2

HCID 13983141,2,5-Thiadiazole-3-carboxylic acidHCID 135892372H-Indol-2-one, 5,6-diamino-1,3-dihydro-3,3-dimethyl-

生成物 1

HCID 178429215HCID 178429215、化合物

実験手順

2.0 g. (15.3 mmol) 1,2,5-thiadiazole-3-carboxylic acid and 2.6 g. (13.6 mmol) 5,6-diamino-3,3-dimethyl-indolin-2-one are heated in 40 ml. polyphosphoric acid under an atmosphere of nitrogen for 2 hours at 160° C. The warm solution is poured on to ice water, worked up and the crystals obtained are filtered off with suction. The residue is again suspended in water, neutralised with an aqueous solution of ammonia, filtered off with suction and recrystallised from methanol with the addition of charcoal. Yield: 2.6 g. (66% of theory); m.p. >300° C.

後処理

  1. customthe crystals obtained
  2. filtrationare filtered off with suction
  3. filtrationfiltered off with suction
  4. customrecrystallised from methanol with the addition of charcoal

出典と根拠

ORDレコード
ord-b7abef2b545641bb89caf351f6761fe4
出典データセット
uspto-grants-1989_05
特許番号
US04835280

関連ノート

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