Acetamide → N-Cyclohexylacetamide

HRID 1763090

反応式

HRID 1763090 の反応式
[C:1]([NH2:4])(=[O:3])[CH3:2].[CH:5]1(Br)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1>[N+](CC)([O-])=O>[CH:5]1([NH:4][C:1](=[O:3])[CH3:2])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1

参加物

4

反応物 2

HCID 178AcetamideHCID 7960Cyclohexyl bromide

生成物 1

HCID 14301N-Cyclohexylacetamide収率 57%

試薬・触媒・溶媒 1

HCID 6587Nitroethane溶媒

実験手順

To 200 ml of nitroethane, were added 12 g of acetamide, 105 of MP-500, which was also used in Example 68, and 41 g of cyclohexylbromide. They were reacted at 60° C. for 5 hours with stirring. After the reaction, the ionexchange resin was filtered off and the resulting filtrate was distilled under reduced pressure to remove the solvent and unreacted raw materials. The resulting distillation residue was recrystallized from petroleum ether, thereby obtaining 16 g of N-cyclohexylacetamide having a melting point of 108°-109° C.(yield: 57%).

後処理

  1. customThey were reacted at 60° C. for 5 hours
  2. customAfter the reaction
  3. filtrationthe ionexchange resin was filtered off
  4. distillationthe resulting filtrate was distilled under reduced pressure
  5. customto remove the solvent and unreacted raw materials
  6. distillationThe resulting distillation residue
  7. customwas recrystallized from petroleum ether

出典と根拠

ORDレコード
ord-7f86d81b8b8140669053b595b2ec87c8
出典データセット
uspto-grants-1989_05
特許番号
US04835312

関連ノート

読み込み中…