Benzyl Chloride → N-Benzylcrotonamide

HRID 1763092ノート

反応式

HRID 1763092 の反応式
[C:1]([NH2:6])(=[O:5])/[CH:2]=[CH:3]/[CH3:4].[CH2:7](Cl)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CN(C)C=O>[CH2:7]([NH:6][C:1](=[O:5])/[CH:2]=[CH:3]/[CH3:4])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 7503Benzyl ChlorideHCID 53544872-Butenamide

生成物 1

HCID 2313079N-Benzylcrotonamide収率 71%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To 200 ml of N,N-dimethylformamide, were added 17 g of crotonamide, 105 g of LEVATIT MP-500, which was also used in Example 68, and 32 g of benzylchloride. They were reacted at 50° C. for 4 hours with stirring. After the reaction, the reaction solution was treated in the same manner as in Example 69, the resulting distillation residue was recrystallized from benzine, and 25 of N-benzylcrotonamide having a melting point of 112.5°-113.6° C. was obtained (yield: 71%).

後処理

  1. customThey were reacted at 50° C. for 4 hours
  2. customAfter the reaction
  3. additionthe reaction solution was treated in the same manner as in Example 69
  4. distillationthe resulting distillation residue
  5. customwas recrystallized from benzine, and 25 of N-benzylcrotonamide having a melting point of 112.5°-113.6° C.
  6. customwas obtained (yield: 71%)

出典と根拠

ORDレコード
ord-0d5f89ffa64b4db3a7c5df88b628343f
出典データセット
uspto-grants-1989_05
特許番号
US04835312

反応ノート

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