Sodium Hydroxide → 3-Amino-9-ethylcarbazole

HRID 1763218

反応式

HRID 1763218 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:8]([CH2:17][CH3:18])[C:9]3[C:14]([C:15]=2[CH:16]=1)=[CH:13][CH:12]=[CH:11][CH:10]=3)([O-])=O.[OH-].[Na+]>Cl.O>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[N:8]([CH2:17][CH3:18])[C:9]3[C:14]([C:15]=2[CH:16]=1)=[CH:13][CH:12]=[CH:11][CH:10]=3

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 665739-ethyl-3-nitro-9H-carbazole

生成物 1

HCID 85883-Amino-9-ethylcarbazole収率 82.8%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 962Water溶媒

実験手順

A solution of 10.2 g of 3-nitro-N-ethylcarbazole (42.5 mmol) and 38.4 g of stannous chloride dihydrate (170 mmol) in 100 ml of concentrated hydrochloric acid was heated for 3 hours at 92° C. The ice cooled solution was (cautiously) made basic by partial addition of a solution of 75 g sodium hydroxide in 150 ml of water. The product was filtered off and washed with the above base solution, followed by copious amounts of water, and then air dried. Vacuum drying and recrystallization from pyridine/water gave 7.4 g light-green needles (82% yield) mp b 109°-11° C.

後処理

  1. filtrationThe product was filtered off
  2. washwashed with the above base solution
  3. customair dried
  4. customVacuum drying
  5. customrecrystallization from pyridine/water

出典と根拠

ORDレコード
ord-2e9d8db71f794180825067f2db8a5a8d
出典データセット
uspto-grants-1978_09
特許番号
US04111850

関連ノート

読み込み中…