Tert-Butylamine → 1-(tert-Butylamino)-3-[2-(6-chloropyridazin-3-yl)phenoxy]propan-2-ol
反応式
[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH:16]2[O:18][CH2:17]2)=[CH:6][CH:7]=1.[C:19]([NH2:23])([CH3:22])([CH3:21])[CH3:20]>CO>[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH:16]([OH:18])[CH2:17][NH:23][C:19]([CH3:22])([CH3:21])[CH3:20])=[CH:6][CH:7]=1参加物
4
実験手順
A mixture of 3-chloro-6-(2-epoxypropoxyphenyl)pyridazine (0.7 g), methanol (7 ml) and t-butylamine (1.7 ml) was stirred and heated under reflux for 11/4 hours. The mixture was evaporated under reduced pressure at 50° and the residue was recrystallised from toluene to give the title product (1.28 g) m.p. 136.5°-137.5°.
後処理
- temperatureheated