Aluminum(III) Chloride → HCID 20309528、化合物

HRID 1763313ノート

反応式

HRID 1763313 の反応式
[CH3:1][NH:2][C:3](=[O:18])[CH2:4][CH2:5][C:6](=[O:17])[C:7]1[C:12]([O:13][CH3:14])=[CH:11][CH:10]=[CH:9][C:8]=1[O:15]C.[Cl-].[Al+3].[Cl-].[Cl-]>ClC1C=CC=CC=1>[CH3:1][NH:2][C:3](=[O:18])[CH2:4][CH2:5][C:6](=[O:17])[C:7]1[C:12]([O:13][CH3:14])=[CH:11][CH:10]=[CH:9][C:8]=1[OH:15]

参加物

4

反応物 2

HCID 6451240Aluminum(III) ChlorideHCID 20309506HCID 20309506、化合物

生成物 1

HCID 20309528HCID 20309528、化合物

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

実験手順

N-Methyl 3-(2,6-dimethoxybenzoyl)propionamide was demethylated with aluminium chloride in chlorobenzene to give N-methyl 3-(2-hydroxy-6-methoxybenzoyl)propionamide, m.p. 125° which may also be prepared from a by-product, N-methyl 3-(2,6-dihydroxybenzoyl)propionamide, by selective methylation with methyl iodide and potassium carbonate in acetone. (iii) By subjecting N-methyl 3-(2-hydroxy-6-methoxybenzoyl)-propionamide to a series of reactions similar to those described in Examples 1(i-ii) and 2(i-v), the title compound may be prepared.

出典と根拠

ORDレコード
ord-fe645e36123b414187ba1e7960efccd6
出典データセット
uspto-grants-1978_09
特許番号
US04111936

反応ノート

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