Phosgene → HCID 54349766、化合物

HRID 1763360ノート

反応式

HRID 1763360 の反応式
[C:1](Cl)(Cl)=[O:2].[Cl:5][CH2:6][C:7]1[S:11][C:10]([NH2:12])=[N:9][N:8]=1>C(OCC)(=O)C>[Cl:5][CH2:6][C:7]1[S:11][C:10]([N:12]=[C:1]=[O:2])=[N:9][N:8]=1

参加物

4

反応物 2

HCID 6371PhosgeneHCID 150317065-(Chloromethyl)-1,3,4-thiadiazol-2-amine

生成物 1

HCID 54349766HCID 54349766、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

A saturated solution of phosgene in ethyl acetate (100 ml) is charged into a glass reaction vessel equipped with a mechanical stirrer. A slurry of 5-chloromethyl-2-amino-1,3,4-thiadiazole (10 grams) in ethyl acetate (300 ml) is added to the reaction vessel, and the resulting mixture is stirred for a period of about 16 hours resulting in the formation of a precipitate. The reaction mixure is then purged with nitrogen gas to remove unreacted phosgene. The purged mixture is then filtered to recover the desired product 5-chloromethyl-1,3,4-thiadiazol-2-yl isocyanate dimer as a solid.

後処理

  1. customequipped with a mechanical stirrer
  2. customresulting in the formation of a precipitate
  3. customThe reaction mixure is then purged with nitrogen gas
  4. customto remove unreacted phosgene
  5. filtrationThe purged mixture is then filtered
  6. customto recover the desired product 5-chloromethyl-1,3,4-thiadiazol-2-yl isocyanate dimer as a solid

出典と根拠

ORDレコード
ord-0f48f4ca7f2844fd8fc681fd038060f3
出典データセット
uspto-grants-1978_09
特許番号
US04111949

反応ノート

読み込み中…