Triethylamine → 5-(4-Fluorobenzoyloxy)-3-methyl-4-phenyl-1-(alpha-methyl-3,4-dichlorobenzyl)-pyrazole

HRID 1763560ノート

反応式

HRID 1763560 の反応式
[CH3:1][C:2]1[NH:3][N:4]([CH:14]([CH3:23])[C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=2)[C:5](=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N(CC)CC)C.[F:31][C:32]1[CH:40]=[CH:39][C:35]([C:36](Cl)=[O:37])=[CH:34][CH:33]=1>O1CCOCC1>[F:31][C:32]1[CH:40]=[CH:39][C:35]([C:36]([O:13][C:5]2[N:4]([CH:14]([CH3:23])[C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=3)[N:3]=[C:2]([CH3:1])[C:6]=2[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[O:37])=[CH:34][CH:33]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 678794-Fluorobenzoyl chlorideHCID 203358943-Methyl-4-phenyl-1-(alpha-methyl-3,4-dichlorobenzyl)-5-pyrazolone

生成物 1

HCID 203358595-(4-Fluorobenzoyloxy)-3-methyl-4-phenyl-1-(alpha-methyl-3,4-dichlorobenzyl)-pyrazole

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

0.1 mol (34.7 g) of 3-methyl-4-phenyl-1-(α-methyl-3,4-dichlorobenzyl)-5-pyrazolone was dissolved in 300 ml of absolute dioxane. After adding 15 ml of triethylamine, 0.11 mol (17 g) of p-fluorobenzoyl chloride in dioxane was added dropwise. After heating for several hours under reflux, the reaction batch was worked up as follows.

後処理

  1. additionwas added dropwise
  2. temperatureAfter heating for several hours
  3. temperatureunder reflux

出典と根拠

ORDレコード
ord-dd297b95e2ab4610a6ffe85fbfa5bfdf
出典データセット
uspto-grants-1978_09
特許番号
US04112109

反応ノート

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