4-Pyridinemethanamine → 1-(3-Fluorophenyl)-3-(pyridin-4-ylmethyl)thiourea

HRID 1763565

反応式

HRID 1763565 の反応式
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1.NC[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[N:12]=1.NCCC1C=CC(CC)=CN=1.NC1C(C)=NC=C(CN)C=1.NCC1C(Cl)=CC=CN=1.NCC1C=C(C2C=CC=CC=2)C=CN=1.NCC1C=C(CC2C=CC=CC=2)C=CN=1.NCC1C=C(OC)C=CN=1.NCC1C=C([S:95][CH3:96])C=CN=1.[N+](C1C=NC=CC=1)([O-])=O.NCC1C(NCC)=CC=CN=1.NCC1C(N(CC)CC)=CC=CN=1.NCC1C=C(NC(=O)C)C=CN=1.NCC1C=C(C(F)(F)[F:151])C=CN=1>>[F:151][C:11]1[CH:17]=[C:13]([NH:12][C:96]([NH:1][CH2:2][C:3]2[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=2)=[S:95])[CH:14]=[CH:15][CH:16]=1

参加物

15

反応物 14

HCID 773174-PyridinemethanamineHCID 1376303-NitropyridineHCID 246721(6-Methylpyridin-2-yl)methanamineHCID 3682810[4-(Trifluoromethyl)pyridin-2-yl]methanamineHCID 156191875-(Aminomethyl)-2-methylpyridin-3-amineHCID 198635004-Phenyl-2-pyridinemethanamineHCID 203104462-(Aminomethyl)-3-diethylaminopyridineHCID 20310472N-(2-(Aminomethyl)pyridin-4-yl)acetamideHCID 203104802-(Aminomethyl)-4-methylthiopyridineHCID 203104822-(5-Ethylpyridin-2-YL)ethanamineHCID 203104882-(Aminomethyl)-3-ethylaminopyridineHCID 203105032-(Aminomethyl)-4-benzylpyridineHCID 21280361(3-Chloropyridin-2-yl)methanamineHCID 22292761(4-Methoxypyridin-2-yl)methanamine

生成物 1

HCID 7975291-(3-Fluorophenyl)-3-(pyridin-4-ylmethyl)thiourea

実験手順

Similarly, following the above procedure but replacing the 4-aminomethylpyridine as used therein with an equal molar proportion of 2-aminomethyl-6-methylpyridine, 2-(2-aminoethyl)-5-ethylpyridine, 3-amino-5-(aminomethyl)-2-methylpyridine, 2-(aminomethyl)-3-chloropyridine, 2-(aminomethyl)-4-phenylpyridine, 2-(aminomethyl)-4-benzylpyridine, 2-(aminomethyl)-4-methoxypyridine, 2-(aminomethyl)-4-methylthiopyridine, 2-aminomethyl)-3-nitropyridine, 2-(aminomethyl)-3-ethylaminopyridine, 2-(aminomethyl)-3-diethylaminopyridine, 2-(aminomethyl)-4-acetylaminopyridine, and 2-(aminomethyl)-4-trifluoromethylpyridine, respectively, all of which may be prepared by reduction of the corresponding nitrile of formula (IVC) according to the method of Sculley, et al., supra., there is obtained

後処理

  1. custom, there is obtained

出典と根拠

ORDレコード
ord-3827ead1dea846eeb89074e908757f56
出典データセット
uspto-grants-1978_09
特許番号
US04112100

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