Hydrochloric Acid → O-Methyl-D-tyrosine--hydrogen chloride (1/1)
反応式
C([NH:4][C@@H:5]([C:15]([OH:17])=[O:16])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)(=O)C.O.[ClH:19]>CN(C=O)C>[ClH:19].[CH3:14][O:13][C:10]1[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([C:15]([OH:17])=[O:16])[NH2:4])=[CH:12][CH:11]=1参加物
5
実験手順
N-Acetyl-O-methyl-D-tyrosine, 24 g. is heated in 100 ml. of water and 100 ml. of concentrated hydrochloric acid for seven hours on a steam bath and let cool to room temperature overnight. The flask is swirled gently and the product crystallizes. It is separated by filtration, washed with a small amount of isopropanol, then with ether and dried to give 16.1 g. of the above named compound, [α]D23 +7.4° (c 2.02, DMF).
後処理
- temperatureis heated in 100 ml
- customthe product crystallizes
- customIt is separated by filtration
- washwashed with a small amount of isopropanol
- dry with materialwith ether and dried
- customto give 16.1 g
出典と根拠
- ORDレコード
- ord-f74537e69b9c46fd969eace7bd4db216
- 出典データセット
- uspto-grants-1978_09
- 特許番号
- US04111923
反応ノート
読み込み中…