1H-imidazole-2-carbaldehyde → HCID 23346561、化合物

HRID 1764045ノート

反応式

HRID 1764045 の反応式
[CH3:1][CH:2]1[CH2:6][CH2:5][C:4]2([C:11]([CH3:13])([CH3:12])[CH2:10][CH2:9][CH2:8][C:7]2([CH3:15])[OH:14])[O:3]1.[CH:16](C1NC=CN=1)=[O:17]>>[CH:16]([O:14][C:7]1([CH3:15])[CH2:8][CH2:9][CH2:10][C:11]([CH3:13])([CH3:12])[C:4]21[O:3][CH:2]([CH3:1])[CH2:6][CH2:5]2)=[O:17]

参加物

3

反応物 2

HCID 249551H-imidazole-2-carbaldehydeHCID 654286-Hydroxydihydrotheaspirane

生成物 1

HCID 23346561HCID 23346561、化合物

実験手順

0.4 g (0.002 M) of 2,6,10,10-tetramethyl-1-oxa-spiro[4.5]decan-6-ol -- isomer A; see Example 1 -- were intimately mixed with 0.5 g (0.005 M) of freshly sublimated formylimidazole and then kept for 2 days at room temperature. The reaction mixture was then extracted with ether and the organic layer washed, dried, evaporated and finally subjected to a fractional distillation to give 0.3 g of a product having b.p. 70°-80°/0.5 Torr and containing 60% of the desired ester. An analytical sample was purified by vapour phase chromatography.

後処理

  1. extractionThe reaction mixture was then extracted with ether
  2. washthe organic layer washed
  3. customdried
  4. customevaporated
  5. distillationfinally subjected to a fractional distillation

出典と根拠

ORDレコード
ord-aac398c990874d629dd797e75c4f54eb
出典データセット
uspto-grants-1978_09
特許番号
US04114630

反応ノート

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