Dimethylamine → 4-Dimethylamino-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine

HRID 1764096ノート

反応式

HRID 1764096 の反応式
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]2[N:14]([CH3:18])[N:15]=[C:16]([CH3:17])[C:3]=12.[CH3:19][NH:20][CH3:21]>>[CH3:19][N:20]([CH3:21])[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]2[N:14]([CH3:18])[N:15]=[C:16]([CH3:17])[C:3]=12

参加物

3

反応物 2

HCID 674DimethylamineHCID 227705064-chloro-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine

生成物 1

HCID 227704984-Dimethylamino-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine

実験手順

15.5 gms. of 4-chloro-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine (0.06 mol.) are added to 132 ml. of a solution of dimethylamine (40%). The reaction mixture is heated at 190°-200° C. for 16 hours in an autoclave and after cooling to room temperature is evaporated in vacuo. The residue is treated with water and extracted with ether. After evaporation of the extract, the 4-dimethylamino-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine (15.6 gms. = 98%) is recrystallized from ligroin, m.p. 90°-91° C.

後処理

  1. temperatureThe reaction mixture is heated at 190°-200° C. for 16 hours in an autoclave
  2. customis evaporated in vacuo
  3. additionThe residue is treated with water
  4. extractionextracted with ether
  5. customAfter evaporation of the extract
  6. customthe 4-dimethylamino-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine (15.6 gms. = 98%) is recrystallized from ligroin, m.p. 90°-91° C.

出典と根拠

ORDレコード
ord-4264836c56804627b9e7643e4485dd31
出典データセット
uspto-grants-1978_09
特許番号
US04115394

反応ノート

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