p-(1-Cyclooctenyl)-anisol → p-(1-Cyclooctenyl)-phenol

HRID 1764129

反応式

HRID 1764129 の反応式
[C:1]1([C:9]2[CH:14]=[CH:13][C:12]([O:15]C)=[CH:11][CH:10]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.Cl.N1C=CC=CC=1>O>[C:1]1([C:9]2[CH:10]=[CH:11][C:12]([OH:15])=[CH:13][CH:14]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1

参加物

4

反応物 2

HCID 284297p-(1-Cyclooctenyl)-anisolHCID 10176127Pyridinium chloride

生成物 1

HCID 53964233p-(1-Cyclooctenyl)-phenol

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
180 °C

実験手順

80 Grams of p-(1-cyclooctenyl)-anisol and 175 g of pyridine-hydrochloride are thoroughly mixed and heated for 4 hours under nitrogen to 180° C. The mixture is cooled, treated with water and extracted with benzene. The benzene extracts are shaken with 3×100 ml of N-sodium hydroxide solution. The alkaline phase is acidified with 2N hydrochloric acid and extracted with ether. The ether solution is dried over sodium sulphate and evaporated. The residue is recrystallised from benzene-petroleum ether to yield the p-(1-cyclooctenyl)-phenol (m.p. 95°-97° C).

後処理

  1. temperatureThe mixture is cooled
  2. extractionextracted with benzene
  3. extractionextracted with ether
  4. dry with materialThe ether solution is dried over sodium sulphate
  5. customevaporated
  6. customThe residue is recrystallised from benzene-petroleum ether

出典と根拠

ORDレコード
ord-f746f2763f964198a8ba9a3117101512
出典データセット
uspto-grants-1978_09
特許番号
US04115416

関連ノート

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