Ethyl 2-bromodecanoate → alpha-[p-(1-Cyclooctenyl)-phenoxy]-decanoic acid ethyl ester

関与物質

反応条件

反応手順

To 2.1 g of sodium in 100 ml of absolute ethanol are added stirring 15 g of p-(1-cyclooctenyl)-phenol. After stirring has continued for a further 30 minutes, 31.5 g of 2-bromo-decanoic acid ethyl ester are slowly added dropwise to this solution and the mixture is maintained at 50° C for 24 hours. After the solvent has been removed in vacuo, the residue is partitioned at 0° C between ether and 2N sodium hydroxide solution. The organic phase is washed until neutral, dried over sodium sulphate and evaporated in vacuo, to thus yield the oily α-[p-(1-cyclooctenyl)-phenoxy]-decanoic acid ethyl ester of the formula ##STR11##

情報源と証拠