Morpholine → 4-(3-Chloro-6-methylpyrazin-2-yl)morpholine

HRID 1764333ノート

反応式

HRID 1764333 の反応式
[Cl:1][C:2]1[C:7](Cl)=[N:6][C:5]([CH3:9])=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>CCOCC>[Cl:1][C:2]1[C:7]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[N:6][C:5]([CH3:9])=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 128581342,3-Dichloro-5-methylpyrazine

生成物 1

HCID 570620344-(3-Chloro-6-methylpyrazin-2-yl)morpholine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

16.3 g of 2,3-dichloro-5-methyl-pyrazine and 100 ml of morpholine are warmed to 100° C. for 6 hours. The reaction mixture is then diluted with 200 ml of ether and again extracted by shaking with water. The ether phase is dried over sodium sulphate and evaporated in a water-pump vacuum. The residue is distilled in a waterpump vacuum. 2-Chloro-3-morpholinyl-5-methyl-pyrazine, boiling point 166°-167° C./15 mm Hg, is thus obtained.

後処理

  1. extractionagain extracted
  2. dry with materialThe ether phase is dried over sodium sulphate
  3. customevaporated in a water-pump vacuum
  4. distillationThe residue is distilled in a waterpump vacuum

出典と根拠

ORDレコード
ord-51f0ee88aed04e299c05c8e0463af3e1
出典データセット
uspto-grants-1978_09
特許番号
US04115575

反応ノート

読み込み中…