Ammonia → HCID 20483508、化合物

HRID 1764337ノート

反応式

HRID 1764337 の反応式
[CH:1]([NH:4][CH2:5][CH:6]([OH:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]#[N:16])=[CH:11][N:10]=1)([CH3:3])[CH3:2].N>CO.[Ni]>[NH2:16][CH2:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][CH:6]([OH:17])[CH2:5][NH:4][CH:1]([CH3:2])[CH3:3])=[N:10][CH:11]=1

参加物

5

反応物 2

HCID 222AmmoniaHCID 204835186-{2-Hydroxy-3-[(propan-2-yl)amino]propoxy}pyridine-3-carbonitrile

生成物 1

HCID 20483508HCID 20483508、化合物

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

12.5 g of 2-(3'-isopropylamino-2'-hydroxy-propoxy)-5-cyano-pyridine are dissolved in 100 ml of methanol. 5-7 g of ammonia are added to the solution and after adding 3 g of Raney nickel hydrogenation is carried out at 70°-80° C. and 40 bars initial pressure of hydrogen, until the absorption of hydrogen ceases. The catalyst is filtered off, the solution is evaporated and the residue is distilled in a bulb tube at 140° C./0.01 mm Hg. 5-Aminomethyl-2-(3'-isopropylamino-2'-hydroxy-propoxy)-pyridine is thus obtained as a slightly yellowish oil.

後処理

  1. customis carried out at 70°-80° C.
  2. custom40 bars initial pressure of hydrogen, until the absorption of hydrogen ceases
  3. filtrationThe catalyst is filtered off
  4. customthe solution is evaporated
  5. distillationthe residue is distilled in a bulb tube at 140° C./0.01 mm Hg

出典と根拠

ORDレコード
ord-1b4ad9eaada24d8ea08cd2321b42496d
出典データセット
uspto-grants-1978_09
特許番号
US04115575

反応ノート

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