Thiophenol → 2-Chloro-3-(phenylsulfanyl)pyrazine
反応式
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:8][C:9]1[C:14](Cl)=[N:13][CH:12]=[CH:11][N:10]=1.C[O-].[Na+]>C(O)C>[Cl:8][C:9]1[C:14]([S:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:13][CH:12]=[CH:11][N:10]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
22 g (0.2 mol) of thiophenol and 29.8 g (0.2 mol) of 2,3-dichloropyrazine are successively added dropwise to a solution of 10.8 g (0.2 mol) of sodium methylate in 200 ml of ethanol and the mixture is stirred for 1 hour. The reaction mixture is then cooled to 0° C. and the reaction product which has precipitated is filtered off and washed with ethanol and water. After drying, 2-chloro-3-phenylthiopyrazine, melting point 100°-111° C., is obtained.
後処理
- customthe reaction product which has precipitated
- filtrationis filtered off
- washwashed with ethanol and water
- customAfter drying
出典と根拠
- ORDレコード
- ord-c9d6fc8559bc45ea91931cb2a1386e7e
- 出典データセット
- uspto-grants-1978_09
- 特許番号
- US04115575
反応ノート
読み込み中…