1-(4-methoxybenzyl)-1H-tetrazole-5-carbonyl chloride → 1-(4-methoxybenzyl)-N-[2-cyano-3-(2-methyl-4-morpholinyl)phenyl]-1H-tetrazole-5-carboxamide
反応式
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][N:8]2[C:12]([C:13](Cl)=[O:14])=[N:11][N:10]=[N:9]2)=[CH:5][CH:4]=1.[NH2:18][C:19]1[CH:26]=[CH:25][CH:24]=[C:23]([N:27]2[CH2:32][CH2:31][O:30][CH:29]([CH3:33])[CH2:28]2)[C:20]=1[C:21]#[N:22]>>[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][N:8]2[C:12]([C:13]([NH:18][C:19]3[CH:26]=[CH:25][CH:24]=[C:23]([N:27]4[CH2:32][CH2:31][O:30][CH:29]([CH3:33])[CH2:28]4)[C:20]=3[C:21]#[N:22])=[O:14])=[N:11][N:10]=[N:9]2)=[CH:5][CH:4]=1参加物
3
実験手順
In a manner similar to Example I, 1-(4-methoxybenzyl)-1H-tetrazole-5-carbonyl chloride is condensed with 2-amino-6-(2-methyl-4-morpholinyl)benzonitrile to give 1-(4-methoxybenzyl)-N-[2-cyano-3-(2-methyl-4-morpholinyl)phenyl]-1H-tetrazole-5-carboxamide.
出典と根拠
- ORDレコード
- ord-f625d22b267e40c79765abf4d9a30dc6
- 出典データセット
- uspto-grants-1978_09
- 特許番号
- US04116960
反応ノート
読み込み中…