Chloroacetanilide → N-phenyl-2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetamide

HRID 1764452

反応式

HRID 1764452 の反応式
[S:1]1([C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:5](=[O:6])[NH:4]1)(=[O:3])=[O:2].[Na].Cl[CH2:15][C:16]([NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:17]>CN(C)C=O>[C:19]1([NH:18][C:16]([CH2:15][N:4]2[C:5](=[O:6])[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[S:1]2(=[O:2])=[O:3])=[O:17])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

4

反応物 2

HCID 11485ChloroacetanilideHCID 24181110Benzosulfinide sodium; Garantose sodium

生成物 1

HCID 677934N-phenyl-2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetamide収率 62.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 22.6g (0.11 mole) of sodium saccharin and 16.7g (0.1 mole) of N-chloroacetylaniline in 150ml of dimethylformamide is heated on a steam bath for one hour, allowed to stir at room temperature for 16 hrs. and poured into ice-water. The resulting precipitate is collected and dissolved in dichloromethane. This solution is dried over magnesium sulfate, and the solvent is evaporated. The residue is recrystallized from methanol to give 19.9g of product, mp. 180°-182° C. EXAMPLE 2 ##STR5##

後処理

  1. customThe resulting precipitate is collected
  2. dissolutiondissolved in dichloromethane
  3. dry with materialThis solution is dried over magnesium sulfate
  4. customthe solvent is evaporated
  5. customThe residue is recrystallized from methanol

出典と根拠

ORDレコード
ord-57a689350faf440db8502e219738db50
出典データセット
uspto-grants-1978_09
特許番号
US04116964

関連ノート

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