Benzeneacetic acid, alpha-methyl-4-(1,3,4,7-tetrahydro-1-oxo-2H-isoindol-2-yl)- → Aluminium alpha-[4-(1-oxo-4,7-dihydro-2-isoindolinyl)phenyl]propionate

HRID 1764497

反応式

[O:1]=[C:2]1[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH2:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([OH:20])=[O:19])=[CH:13][CH:12]=1.O.O.O.O.O.O.[Cl-].[Al+3:29].[Cl-].[Cl-]>O>[O:1]=[C:2]1[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH2:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([O-:20])=[O:19])=[CH:13][CH:12]=1.[Al+3:29].[O:1]=[C:2]1[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH2:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([O-:20])=[O:19])=[CH:13][CH:12]=1.[O:1]=[C:2]1[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH2:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([O-:20])=[O:19])=[CH:13][CH:12]=1

参加物

実験手順

A mixture of 8.37 g (0.03 mole) of α-[4-(1-oxo-4,7-dihydro-2-isoindolinyl)phenyl]propionic acid and 30 ml of water was stirred for about 1 hour. At the end of this time, a solution of 2.41 g (0.01 mole) of aluminium chloride hexahydrate in 50 ml of water was added to the resulting solution. The white precipitate which was produced was collected by filtration and washed with 75 ml of water. The resulting white solid was then dried at 105° C. for 4 hours. There were obtained 9.0 g of a white solid, sparingly soluble in most organic solvents, slightly soluble in dimethyl sulphoxide and having a melting point above 300° C.

後処理

customThe white precipitate which was produced
filtrationwas collected by filtration
washwashed with 75 ml of water
customThe resulting white solid was then dried at 105° C. for 4 hours

出典と根拠

ORDレコード: ord-9756a47165b84f16b5895d7d98b48bcf
出典データセット: uspto-grants-1978_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04116972

反応式

参加物

反応物 2

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

関連ノート