4-Methoxybenzenesulfonyl chloride → 5-Chloro-3-(4-hydroxyphenylsulfonyl)-2-phenylbenzofuran
反応式
ClC1C=CC2OC(C3C=CC=CC=3)=CC=2C=1.COC1C=CC(S(Cl)(=O)=O)=CC=1.[Cl:29][C:30]1[CH:31]=[CH:32][C:33]2[O:37][C:36]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)=[C:35]([S:44]([C:47]3[CH:52]=[CH:51][C:50]([O:53]C)=[CH:49][CH:48]=3)(=[O:46])=[O:45])[C:34]=2[CH:55]=1>>[Cl:29][C:30]1[CH:31]=[CH:32][C:33]2[O:37][C:36]([C:38]3[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=3)=[C:35]([S:44]([C:47]3[CH:52]=[CH:51][C:50]([OH:53])=[CH:49][CH:48]=3)(=[O:46])=[O:45])[C:34]=2[CH:55]=1参加物
4
実験手順
Acylation of 5-chloro-2-phenylbenzofuran with 4-methoxybenzenesulfonyl chloride as described in Example 1 followed by demethylation of the 5-chloro-3-(4-methoxyphenylsulfonyl)-2-phenylbenzofuran thus formed also as described therein, gives 5-chloro-3-(4-hydroxyphenylsulfonyl)-2-phenylbenzofuran.