4-Methoxybenzenesulfonyl chloride → HCID 22768858、化合物

反応式

FC(F)(F)C1C=C(C=CC=1)CC1OC2C=CC=CC=2C=1.COC1C=CC(S(Cl)(=O)=O)=CC=1.C[O:34][C:35]1[CH:40]=[CH:39][C:38]([S:41]([C:44]2[C:48]3[CH:49]=[CH:50][CH:51]=[CH:52][C:47]=3[O:46][C:45]=2[CH2:53][C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([C:60]([F:63])([F:62])[F:61])[CH:55]=2)(=[O:43])=[O:42])=[CH:37][CH:36]=1>>[OH:34][C:35]1[CH:36]=[CH:37][C:38]([S:41]([C:44]2[C:48]3[CH:49]=[CH:50][CH:51]=[CH:52][C:47]=3[O:46][C:45]=2[CH2:53][C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([C:60]([F:63])([F:62])[F:61])[CH:55]=2)(=[O:43])=[O:42])=[CH:39][CH:40]=1

参加物

反応物 3

HCID 74014-Methoxybenzenesulfonyl chloride

HCID 22768889HCID 22768889、化合物

HCID 227688952-{[3-(Trifluoromethyl)phenyl]methyl}-1-benzofuran

生成物 1

HCID 22768858HCID 22768858、化合物

実験手順

Acylation of 2-(3-trifluoromethylbenzyl)benzofuran with 4-methoxybenzenesulfonyl chloride as described in the procedure described above followed by demethylation of the 3-(4-methoxyphenylsulfonyl)-2-(3-trifluoromethylbenzyl)benzofuran thus formed also as described above gives 3-(4-hydroxyphenylsulfonyl)-2-(3-trifluoromethylbenzyl)benzofuran.

後処理

customthus formed also

出典と根拠

ORDレコード: ord-def9e6f44e5c476289b5eb632c7b77ed
出典データセット: uspto-grants-1978_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04117128

反応ノート

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