関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2,3-Dichloronitrobenzene | HCID 18555 | — |
| 反応物 | 3-Chloropropanethiol | HCID 87134 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (2-Chloro-6-nitrophenyl)(3-chloropropyl)sulfane | HCID 22735865 | 100% |
反応手順
To a dry THF (Aldrich anhydrous grade, 70 mL) solution of 2,3-dichloronitrobenzene (9.61 g, 50.1 mmol) and 3-chloropropanethiol (5.0 g, 45.5 mmol) was added in one portion at 23° C. KOH pellets. The resulting mixture was vigorously stirred at 23° C. for 3.5 h. The reaction mixture was filtered through a Celite plug to remove remaining KOH. The plug was washed with THF (2×50 mL). The filtrate was concentrated in vacuo to give crude 1-chloro-2-[(3-chloropropyl)sulfanyl]-3-nitrobenzene (12 g, ˜100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | USRE039679E1 |
|---|
| 出典データセット | uspto-grants-2007_06 |
|---|
| ORD ID | ord-a9c15ca7bb9e4f46bb5ac21caee1abe9 |
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| 出典メモ | uspto-grants-2007_06 |
|---|
