Water → 2-(2,3-dihydro-1H-inden-2-yl)ethanol

HRID 1764887

反応式

HRID 1764887 の反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[CH2:10][C:11](OCC)=[O:12].[H-].[H-].[H-].[H-].[Li+].[Al+3].O>CCOCC.CCOC(C)=O.[O-]S([O-])(=O)=O.[Mg+2]>[CH2:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1][CH:2]1[CH2:10][CH2:11][OH:12]

参加物

7

反応物 3

HCID 962WaterHCID 10104359Ethyl 2-(2,3-dihydro-1H-inden-2-yl)acetateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 103520002-(2,3-dihydro-1H-inden-2-yl)ethanol

試薬・触媒・溶媒 3

HCID 3283Diethyl Ether溶媒HCID 8857Ethyl Acetate溶媒HCID 24083Sulfuric acid magnesium salt (1:1)溶媒

反応条件

温度
0 °C

実験手順

To a solution of ethyl 2,3-dihydro-1H-inden-2-ylacetate (285 mg, 1.39 mmol) in Et2O (5 mL) at 0° C. under N2 was added LAH (53 mg, 1.39 mmol). After stirring for 40 minutes at 0° C., 0.4 mL of H2O was added to quench the reaction. The reaction mixture was diluted with EtOAc (100 mL) and MgSO4 was added with stirring. The reaction mixture was then filtered and concentrated in vacuo to a clear oil. 2-(2,3-dihydro-1H-inden-2-yl)ethanol was isolated without further purification.

後処理

  1. customto quench
  2. customthe reaction
  3. additionwas added
  4. stirringwith stirring
  5. filtrationThe reaction mixture was then filtered
  6. concentrationconcentrated in vacuo to a clear oil

出典と根拠

ORDレコード
ord-b3a625809a514b65994dfe9873c578c1
出典データセット
uspto-grants-2007_06
特許番号
USRE039679E1

関連ノート

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