3-(Trifluoromethoxy)aniline → 4-(3-Trifluoromethoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine

HRID 1765143ノート

反応式

HRID 1765143 の反応式
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1.[F:15][C:16]([F:26])([F:25])[O:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH2:21]>>[F:15][C:16]([F:25])([F:26])[O:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH:21][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1

参加物

3

反応物 2

HCID 737533-(Trifluoromethoxy)anilineHCID 27633954-Chloro-6-methyl-2-(pyridin-2-yl)pyrimidine

生成物 1

HCID 227323534-(3-Trifluoromethoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine

実験手順

The title compound was prepared from 4-chloro-6-methyl-2-(2-pyridinyl)pyrimidine (50 mg, 0.243 mmol) and 3-(trifluoromethoxy)aniline (65 μl, 0.243 mmol) similar to Example 11 and isolated as a pale white solid (78 mg, 93%). 1H NMR (DMSO-d6): 9.95 (s, 1H), 8.74 (s, 1H), 8.31 (d, J=9.3 Hz, 2H), 7.95 (t, J=7.7 Hz, 1H), 7.65 (d, J=8.4 Hz, 1H), 7.53–7.43 (m, 2H), 6.98 (d, J=8.4 Hz, 1H), 6.71 (s, 1H), 2.44 (s, 3H).

出典と根拠

ORDレコード
ord-eb354be4b342419ab7edbaab2e31d476
出典データセット
uspto-grants-2007_06
特許番号
US07226927B2

反応ノート

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