Ethyl formate → HCID 21107219、化合物

反応式

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH2:12][NH:13][CH:14]3[CH2:16][CH2:15]3)[CH:11]=1)[O:8][C:7]([CH3:18])([CH3:17])[CH2:6][C:5]2([CH3:20])[CH3:19].[CH:21](OCC)=[O:22]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH2:12][N:13]([CH:14]3[CH2:15][CH2:16]3)[CH:21]=[O:22])[CH:11]=1)[O:8][C:7]([CH3:18])([CH3:17])[CH2:6][C:5]2([CH3:20])[CH3:19]

参加物

反応物 2

HCID 8025Ethyl formate

HCID 211072186-Bromo-8-[(cyclopropyl-amino)-methyl]-2,2,4,4-tetramethyl-chroman2 回

生成物 1

HCID 21107219HCID 21107219、化合物収率 100%

実験手順

A solution of 6-bromo-8-[(cyclopropyl-amino)-methyl]-2,2,4,4-tetramethyl-chroman (Intermediate 7, 1.4 g, 4.14 mmol) in ethyl formate was refluxed for 6 h. The solvent was distilled off in vacuo to afford the title compound as a clear oil (1.56 g, 100%).

後処理

distillationThe solvent was distilled off in vacuo

出典と根拠

ORDレコード: ord-5f759b52dfae41808718d8e8c453db9e
出典データセット: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07226951B2

反応ノート

読み込み中…

参加物