Formic Acid → N-(3-Bromo-phenyl)-N-methyl-formamide

A solution of 3-bromo-N-methyl aniline (made as described by Lopez et al. in Tet. Lett., 1999, 40, 11, p 2071–2074 incorporated herein by reference; 7.4 g, 39.5 mmol) in formic acid (20 mL) was refluxed for 3 h. The reaction mixture was then cooled to ambient temperature, diluted with water and extracted with diethyl ether. The organic phase was washed with saturated, aqueous sodium bicarbonate solution, water and brine, dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title product as a dark brown oil.

1. extractionextracted with diethyl ether
2. washThe organic phase was washed with saturated, aqueous sodium bicarbonate solution, water and brine
3. dry with materialdried over anhydrous magnesium sulfate
4. filtrationfiltered
5. customevaporated in vacuo

ORDレコード

ord-31943b4824c542868d20773224ae02fe

出典データセット

uspto-grants-2007_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07226951B2