Potassium Carbonate → HCID 57424255、化合物

HRID 1765830ノート

反応式

HRID 1765830 の反応式
[CH:1]([O:4][C:5](=[O:24])[C:6]1[CH:11]=[CH:10][C:9]([C:12]#[C:13][Si](C)(C)C)=[CH:8][C:7]=1[CH2:18][N:19]([CH:21]1[CH2:23][CH2:22]1)[CH3:20])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[CH:1]([O:4][C:5](=[O:24])[C:6]1[CH:11]=[CH:10][C:9]([C:12]#[CH:13])=[CH:8][C:7]=1[CH2:18][N:19]([CH:21]1[CH2:23][CH2:22]1)[CH3:20])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 69076270HCID 69076270、化合物2 回

生成物 1

HCID 57424255HCID 57424255、化合物収率 78%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution 2-[(cyclopropyl-methyl-amino)-methyl]-4-trimethylsilanylethynyl-benzoic acid isopropyl ester (Intermediate 121, 0.34 g, 1 mmol) in methanol (2 mL) was treated with potassium carbonate (0.207 g, 1.5 mmol) and the resulting reaction mixture was stirred at ambient temperature for 4 h. The volatiles were evaporated in vacuo, the residue was diluted with water and extracted with diethyl ether, dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title compound as an oil (0.21 g, 78%).

後処理

  1. customthe resulting reaction mixture
  2. customThe volatiles were evaporated in vacuo
  3. additionthe residue was diluted with water
  4. extractionextracted with diethyl ether
  5. dry with materialdried over anhydrous magnesium sulfate
  6. filtrationfiltered
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-2c1df15a75eb4b4c87af914750d18725
出典データセット
uspto-grants-2007_06
特許番号
US07226951B2

反応ノート

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