HCID 21108202、化合物 → HCID 21108382、化合物
反応式
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([CH:13](O)[CH2:14][CH2:15][N:16]([CH3:18])[CH3:17])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)(=O)C>Cl>[NH:4]1[C:12]2[C:7](=[CH:8][C:9](/[CH:13]=[CH:14]/[CH2:15][N:16]([CH3:18])[CH3:17])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1参加物
3
実験手順
A mixture of 3-[1-acetyl-2,3-dihydro-1H-indol-5-yl]-3-hydroxy-N,N-dimethyl-1-propanamine (3.3 g) obtained in 1) above and concd. hydrochloric acid (20 ml) was heated for 16 hours under reflux. The reaction solution was cooled to room temperature, then concentrated under reduced pressure, diluted with water, made basic with 2 N aqueous sodium hydroxide and extracted with ethyl acetate. The extract was washed with a saturated saline solution and dried over anhydrous magnesium sulfate, and the solvent was distilled away under reduced pressure, whereby the title compound (2.3 g) was obtained as oily matter.
後処理
- customobtained in 1) above and concd
- temperatureunder reflux
- concentration