1-(Diphenylmethyl)-3-[(2-nitrophenylmethyl)amino]-azetidine → 3-[(2-Aminophenylmethyl)amino]-1-(diphenylmethyl)-azetidine

HRID 1766182ノート

反応式

HRID 1766182 の反応式
[C:1]1([CH:7]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:8]2[CH2:11][CH:10]([NH:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[N+:20]([O-])=O)[CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Rh].C>[NH2:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[CH2:13][NH:12][CH:10]1[CH2:9][N:8]([CH:7]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:11]1

参加物

4

反応物 1

HCID 211099031-(Diphenylmethyl)-3-[(2-nitrophenylmethyl)amino]-azetidine

生成物 1

HCID 211099093-[(2-Aminophenylmethyl)amino]-1-(diphenylmethyl)-azetidine

試薬・触媒・溶媒 2

HCID 10080373Rhodium carbon触媒HCID 887Methanol溶媒

実験手順

A solution of 20.0 g (0.5355 mol) of 1-(diphenylmethyl)-3-[(2-nitrophenylmethyl)amino]-azetidine in 200 ml of methanol was hydrogenated in the presence of 4 g of 5% rhodium/charcoal for 5 hours at ambient temperature. The catalyst was filtered off, the filtrate was concentrated by evaporation in vacuo. 17.7 g (96% of theoretical) of a colourless, highly viscous oil were obtained, which was further processed without any additional purification.

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated by evaporation in vacuo
  3. custom17.7 g (96% of theoretical) of a colourless, highly viscous oil were obtained
  4. customwhich was further processed without any additional purification

出典と根拠

ORDレコード
ord-734891da2bc948f3b1ba69c827e3506a
出典データセット
uspto-grants-2007_06
特許番号
US07230001B1

反応ノート

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