(1R,2R)-2-Aminocyclohexanol → 5-Bromo-N-(trans-2-hydroxy-cyclohexyl)-6-(2-methoxy-ethoxy)-nicotinamide

反応式

[Br:1][C:2]1[C:3]([O:11][CH2:12][CH2:13][O:14][CH3:15])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[NH2:16][C@@H:17]1[CH2:22][CH2:21][CH2:20][CH2:19][C@H:18]1[OH:23]>>[Br:1][C:2]1[C:3]([O:11][CH2:12][CH2:13][O:14][CH3:15])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:16][C@@H:17]1[CH2:22][CH2:21][CH2:20][CH2:19][C@H:18]1[OH:23])=[O:9]

参加物

反応物 2

HCID 735777(1R,2R)-2-Aminocyclohexanol

HCID 211097055-Bromo-6-(2-methoxy-ethoxy)-nicotinic acid

生成物 1

HCID 675055315-Bromo-N-(trans-2-hydroxy-cyclohexyl)-6-(2-methoxy-ethoxy)-nicotinamide

実験手順

The title compound was synthesised in analogy to the amide coupling procedure described for the synthesis of Example 1, from 5-bromo-6-(2-methoxy-ethoxy)-nicotinic acid and trans-2-amino-cyclohexanol (commercially available). MS (m/e): 373.1 (MH+).

出典と根拠

ORDレコード: ord-67f3c6511a0d4970a53c63f5bb8af98e
出典データセット: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07229999B2

反応ノート

読み込み中…