2-Methoxyethanol → (RS)-5-(4-chloro-phenyl)-N-(2-hydroxymethyl-butyl)-6-(2-methoxy-ethoxy)-nicotinamide
反応式
CO[C:3](=[O:12])[C:4]1[CH:9]=[C:8](Br)[C:7]([OH:11])=[N:6][CH:5]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17](B(O)O)=[CH:16][CH:15]=1.[NH2:23][CH2:24][CH:25]([CH2:28][CH3:29])[CH2:26][OH:27].[CH3:30][O:31][CH2:32][CH2:33]O>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:8]2[C:7]([O:11][CH2:33][CH2:32][O:31][CH3:30])=[N:6][CH:5]=[C:4]([CH:9]=2)[C:3]([NH:23][CH2:24][CH:25]([CH2:26][OH:27])[CH2:28][CH3:29])=[O:12])=[CH:16][CH:15]=1参加物
5
実験手順
The title compound was synthesized in analogy to Example 102, using 5-bromo-6-hydroxy-nicotinic acid methyl ester, 2-methoxyethanol, (4-chloro-phenyl)-boronic acid and 2-(aminomethyl)-1-butanol (CAS [16519-75-8]) as starting materials to yield (RS)-5-(4-chloro-phenyl)-N-(2-hydroxymethyl-butyl)-6-(2-methoxy-ethoxy)-nicotinamide. MS (ISP) 393.3 (M+H)+.