4-Hydroxymethylpyridine → racemic 5-(4-chloro-phenyl)-N-(2-hydroxymethyl-butyl)-6-(pyridin-4-ylmethoxy)-nicotinamide
反応式
Br[C:2]1[CH:3]=[C:4]([C:9]([OH:11])=O)[CH:5]=[N:6][C:7]=1Cl.[N:12]1[CH:17]=[CH:16][C:15]([CH2:18][OH:19])=[CH:14][CH:13]=1.[Cl:20][C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1.[NH2:30][CH2:31][CH:32]([CH2:35][CH3:36])[CH2:33][OH:34]>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([C:2]2[C:7]([O:19][CH2:18][C:15]3[CH:16]=[CH:17][N:12]=[CH:13][CH:14]=3)=[N:6][CH:5]=[C:4]([CH:3]=2)[C:9]([NH:30][CH2:31][CH:32]([CH2:33][OH:34])[CH2:35][CH3:36])=[O:11])=[CH:23][CH:22]=1参加物
5
実験手順
The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, 4-pyridinemethanol, (4-chloro-phenyl)-boronic acid and 2-aminomethyl-1-butanol as starting materials to yield racemic 5-(4-chloro-phenyl)-N-(2-hydroxymethyl-butyl)-6-(pyridin-4-ylmethoxy)-nicotinamide, MS (ISP) 426.1 (M+H)+.