Cyclopropanemethanol → (RS)-5-(4-cyano-phenyl)-6-cyclopropylmethoxy-N-(2-hydroxymethyl-butyl)-nicotinamide
反応式
Br[C:2]1[CH:3]=[C:4]([C:9]([OH:11])=O)[CH:5]=[N:6][C:7]=1Cl.[OH:12][CH2:13][CH:14]1[CH2:16][CH2:15]1.[C:17]([C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1)#[N:18].[NH2:28][CH2:29][CH:30]([CH2:33][CH3:34])[CH2:31][OH:32]>>[C:17]([C:19]1[CH:24]=[CH:23][C:22]([C:2]2[C:7]([O:12][CH2:13][CH:14]3[CH2:16][CH2:15]3)=[N:6][CH:5]=[C:4]([CH:3]=2)[C:9]([NH:28][CH2:29][CH:30]([CH2:31][OH:32])[CH2:33][CH3:34])=[O:11])=[CH:21][CH:20]=1)#[N:18]参加物
5
実験手順
The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-cyanophenylboronic acid and 2-(aminomethyl)-1-butanol as starting materials to yield (RS)-5-(4-cyano-phenyl)-6-cyclopropylmethoxy-N-(2-hydroxymethyl-butyl)-nicotinamide. MS (ISP) 380.2 (M+H)+.