Potassium Carbonate → 3-(2-Bromo-cyclopent-1-enyl)benzoic Acid Ethyl Ester

関与物質

反応手順

1,2-Dibromocyclopentene (Ex Aldrich, 27,732-0) (5 g, 0.0221 mol), (3-ethoxycarbonylphenyl) boronic acid (Ex Combiblocks inc. BB-2117-005) (4.26 g, 0.0221 mol), Pd(0)[PPh3]4 (0.5 g) and potassium carbonate (5 g) were stirred at 80° C. under nitrogen for 18 h in dimethoxyethane (30 mL). The reaction mixture was then filtered through Kieselguhr and evaporated down to an oil. Purification was carried out on a Biotage (90 g column) using isohexane containing a gradient of dichloromethane (0–30%) to give the required product (wt: 1.15 g i.e. 30% yield)

情報源と証拠