Ethanol → Ethyl 3-bromo-5-methylbenzoate

HRID 1767242

反応式

HRID 1767242 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5]([OH:7])=[O:6].[CH2:12](O)[CH3:13]>S(=O)(=O)(O)O.C(OCC)C.O>[CH2:12]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([CH3:11])[CH:10]=[C:2]([Br:1])[CH:3]=1)[CH3:13]

参加物

5

反応物 2

HCID 702EthanolHCID 34331273-Bromo-5-methylbenzoic acid

生成物 1

HCID 20086624Ethyl 3-bromo-5-methylbenzoate収率 94%

試薬・触媒・溶媒 2

HCID 1118Sulfuric Acid触媒HCID 21584184Diethylether water溶媒

反応条件

温度
90 °C

実験手順

Sulphuric acid (10 drops) was added to 3-bromo-5-methylbenzoic acid (1.18 g, 5.49 mmol) in ethanol (20 ml) and refluxed at 90° C. for 20 hours. After cooling, the mixture was diluted with diethyl ether/water and the organic phase washed with sodium hydrogen bicarbonate (saturated solution), dried (magnesium sulphate) and evaporated to dryness to give the title compound as a pale yellow oil (1.249 g, 94%).

後処理

  1. temperatureAfter cooling
  2. washthe organic phase washed with sodium hydrogen bicarbonate (saturated solution)
  3. dry with materialdried (magnesium sulphate)
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-f743fbd499fe4d2e9d01a567776bde30
出典データセット
uspto-grants-2007_06
特許番号
US07232821B2

関連ノート

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