Ethanol → Ethyl 3-Bromo-5-fluorobenzoate
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:11])[CH:10]=1)[C:5]([OH:7])=[O:6].[CH2:12](O)[CH3:13]>S(=O)(=O)(O)O>[CH2:12]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([F:11])[CH:10]=[C:2]([Br:1])[CH:3]=1)[CH3:13]参加物
4
反応条件
- 温度
- 90 °C
実験手順
Sulphuric acid (5 drops) was added to 3-bromo-5-fluorobenzoic acid (1.194 g, 5.45 mmol) in ethanol (10 ml) and refluxed with stirring at 90° C. for 17 hours. Reaction mixture partitioned between diethyl ether and water, washed with sodium hydrogen carbonate, dried (MgSO4) and evaporated to dryness.
後処理
- temperaturerefluxed
- customReaction mixture
- custompartitioned between diethyl ether and water
- washwashed with sodium hydrogen carbonate
- dry with materialdried (MgSO4)
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-e896d59eecb94405a6fb45a596741757
- 出典データセット
- uspto-grants-2007_06
- 特許番号
- US07232821B2
反応ノート
読み込み中…