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HRID 1767913作成日：2026年10月25日

Lithium Hydroxide → (6-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-4-yl]-ethoxy}-indol-1-yl)-acetic acid

https://huagongshe.com/reaction/1767913

反応式

関与物質

役割名称HCID仕込み量
反応物Lithium HydroxideHCID 3939—
反応物(6-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-4-yl]-ethoxy}-indol-1-yl)-acetic acid tert-butyl esterHCID 69280206—
生成物(6-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-4-yl]-ethoxy}-indol-1-yl)-acetic acidHCID 11317127—

反応手順

In analogy to the procedure described in example 2 c], (6-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-4-yl]-ethoxy}-indol-1-yl)-acetic acid tert-butyl ester was treated with LiOH to obtain (6-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-4-yl]-ethoxy}-indol-1-yl)-acetic acid as off-white crystals.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07235572B2
出典データセットuspto-grants-2007_06
ORD IDord-66b5a9439fa0491592a798102b391602
出典メモuspto-grants-2007_06