Toluene → Ethyl(7-methoxy-1-benzofuran-3-yl)acetate

HRID 1768004

反応式

HRID 1768004 の反応式
[CH3:1][O:2][C:3]1[C:11]2[O:10][CH2:9][C:8](=O)[C:7]=2[CH:6]=[CH:5][CH:4]=1.[C:13]([CH:16]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([OH:15])=[O:14].[C:36]1(C)C=CC=C[CH:37]=1>>[CH2:36]([O:15][C:13](=[O:14])[CH2:16][C:8]1[C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:11]=2[O:10][CH:9]=1)[CH3:37]

参加物

4

反応物 3

HCID 1140TolueneHCID 28181127-Methoxybenzofuran-3(2H)-oneHCID 10870911Carboxymethylene triphenylphosphorane

生成物 1

HCID 22734085Ethyl(7-methoxy-1-benzofuran-3-yl)acetate

実験手順

A mixture of 7-methoxy-benzofuran-3 (2H)-one (1.64 g, 10 mmol) and (carboxymethylene)triphenylphosphorane (5.22 g, 15 mmol) was refluxed in toluene (100 ml) for 48 hrs. At the end, the reaction mixture was concentrated and loaded over silica-gel column. The column was eluted with hexane (500 ml) and later with 25% ethyl acetate. The product, ethyl(7-methoxy-1-benzofuran-3-yl)acetate was obtained as a white oil. Yield: 1.9 g (81%); 235 (M+H).

後処理

  1. concentrationAt the end, the reaction mixture was concentrated
  2. washThe column was eluted with hexane (500 ml) and later with 25% ethyl acetate

出典と根拠

ORDレコード
ord-271ad550a4094ff1868339aa7e1105cd
出典データセット
uspto-grants-2007_06
特許番号
US07235569B2

関連ノート

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