Ammonia → 4-(Imidazo[1,2-a]pyridin-3-yl)piperidin-4-ol

HRID 1768032ノート

反応式

HRID 1768032 の反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]([OH:23])([C:14]2[N:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]3=[N:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.N>C(Cl)Cl>[N:16]1[CH:15]=[C:14]([C:11]2([OH:23])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[N:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=12

参加物

4

反応物 2

HCID 222AmmoniaHCID 69456650HCID 69456650、化合物

生成物 1

HCID 236144534-(Imidazo[1,2-a]pyridin-3-yl)piperidin-4-ol

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 4-hydroxy-4-imidazo[1,2-a]pyridin-3-yl-piperidine-1-carboxylic acid tert-butyl ester (2.0 g 6.26 mmol) in CH2Cl2 (100 ml) trifluoro acetic acid (10 ml) was added at room temperature. The reaction mixture was stirred at room temperature for 24 hrs. At the end, the reaction mixture was basified with methanolic ammonia and concentrated to dryness. The residue was directly chromatographed over silica-gel column and eluted with methanol:10% methanolic ammonia. The product, 4-imidazo[1,2-a]pyridin-3-yl-piperidin-4-ol was obtained as yellow oil; Yield; 620 mg (48%); 218 (M+H).

後処理

  1. concentrationconcentrated to dryness
  2. customThe residue was directly chromatographed over silica-gel column
  3. washeluted with methanol

出典と根拠

ORDレコード
ord-3a5b1d94642e402d8a067c1d4b7dd0fe
出典データセット
uspto-grants-2007_06
特許番号
US07235569B2

反応ノート

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