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HRID 1768142作成日：2026年10月26日

6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → (RS)-2-oxo-1-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid

https://huagongshe.com/reaction/1768142

反応式

関与物質

役割名称HCID仕込み量
反応物6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dioneHCID 79720—
反応物4-(4-Trifluoromethyl-benzyloxy)-phenylamineHCID 22137889—
生成物(RS)-2-oxo-1-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acidHCID 23614753—

反応手順

The title compound is prepared in analogy to Example 3c) from 4-(4-trifluoromethyl-benzyloxy)-phenylamine and 6,6-dimethyl-5,7-dioxa-spiro[2,5]octane-4,8-dione. Yield: 37% of a colorless solid. MS: m/e=380.1 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07235581B2
出典データセットuspto-grants-2007_06
ORD IDord-e82aceb8b5e7496b8dca613177d52431
出典メモuspto-grants-2007_06