Acetic acid, 2-(2-formylphenoxy)- → HCID 18948980、化合物

HRID 1768607ノート

反応式

HRID 1768607 の反応式
[CH:1]([C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[O:5][CH2:6][C:7]([OH:9])=[O:8])=O.[NH2:14]/[C:15](/[CH3:21])=[CH:16]\[C:17]([O:19][CH3:20])=[O:18]>CO>[CH3:20][O:19][C:17]([C:16]1[CH:1]([C:3]2[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=2[O:5][CH2:6][C:7]([OH:9])=[O:8])[C:16]([C:17]([O:19][CH3:20])=[O:18])=[C:15]([CH3:21])[NH:14][C:15]=1[CH3:21])=[O:18]

参加物

4

反応物 2

HCID 46533Acetic acid, 2-(2-formylphenoxy)-HCID 643918Methyl 3-aminocrotonate

生成物 1

HCID 18948980HCID 18948980、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 5 g of 2-formylphenoxyacetic acid and 6.4 g of methyl 3-aminocrotonate in methanol was refluxed for 24 hours and evaporated. The residue was dissolved in a solution of sodium carbonate in water. This solution was washed twice with ethyl acetate and acidified to pH 2 with dilute hydrochloric acid, after which the solution was again extracted with ethyl acetate. The organic layer was dried over magnesium sulfate and evaporated. The residue was crystallized from ethyl acetate/petroleum ether 60-80.

後処理

  1. customevaporated
  2. dissolutionThe residue was dissolved in a solution of sodium carbonate in water
  3. washThis solution was washed twice with ethyl acetate
  4. extractionafter which the solution was again extracted with ethyl acetate
  5. dry with materialThe organic layer was dried over magnesium sulfate
  6. customevaporated
  7. customThe residue was crystallized from ethyl acetate/petroleum ether 60-80

出典と根拠

ORDレコード
ord-230fc64097a04856936656f727631c59
出典データセット
uspto-grants-1995_01
特許番号
US05378718

反応ノート

読み込み中…