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Triethylamine → 1-(1-Adamantyl)-4-(4-chloro-3-oxo-2,3-dihydro-5-pyridazinyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Piperazine, 1-(1-adamantyl)- | HCID 35373 | — |
| 反応物 | 4,5-Dichloro-3-hydroxypyridazine | HCID 73247 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(1-Adamantyl)-4-(4-chloro-3-oxo-2,3-dihydro-5-pyridazinyl)piperazine | HCID 18946304 | 73.7% |
反応手順
A mixture of 1-(1-adamantyl)piperazine (2.2 g, 10 mmol), triethylamine (1.36 ml, 10 mmol) and 4,5-dichloro-3-oxo-2,3-dihydropyridazine (1.65 g, 10 mmol) in ethanol (25 ml) was heated under reflux for 5 hours. After cooling the precipitated solids were collected, washed with ethanol and dried to afford 2.57 g of the title compound, yield: 73.6%, mp. 292°-294° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05380724 |
| 出典データセット | uspto-grants-1995_01 |
| ORD ID | ord-983c00e751b44387b3912056b5a06470 |
| 出典メモ | uspto-grants-1995_01 |