Ethylenediamine → 2-Phenylimidazoline

温度

200 °C

In a 2,000 ml four-necked flask equipped with a reflux condenser and a thermometer were charged 515 g of benzonitrile and 10 g of titanium diisopropoxybis(acetonate). After addition of 4 g of water, the mixture was heated up to 185°-190° C. with stirring. Then, 300 g of ethylenediamine were added dropwise for 10 hours with stirring while maintaining the temperature at 185° C. or above. After completion of the addition of the diamine, the reaction mixture was heated up to 200° C. and maintained at that temperature for 6 hours. The resulting mixture was then subjected to vacuum distillation at 0.7 mmHg and at 160°-180° C. to obtain 635 g of 2-phenyl-2-imidazoline with a yield of 87%.

1. customIn a 2,000 ml four-necked flask equipped with a reflux condenser
2. temperaturethe mixture was heated up to 185°-190° C.
3. stirringwith stirring
4. temperaturewhile maintaining the temperature at 185° C. or above
5. temperaturemaintained at that temperature for 6 hours
6. distillationThe resulting mixture was then subjected to vacuum distillation at 0.7 mmHg and at 160°-180° C.

ORDレコード

ord-5d83af5d36934062a66976d27c27d6de

出典データセット

uspto-grants-1995_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05380899