Tirilazad Mesylate → HCID 14307852、化合物

反応式

[CH3:1][C@@H:2]1[CH2:43][C@@H:42]2[C@:29]([CH3:46])([CH2:30][CH:31]=[C:32]3[C@H:41]2[CH2:40][CH2:39][C:38]2[C@:33]3([CH3:45])[CH:34]=[CH:35][C:36](=[O:44])[CH:37]=2)[C@H:3]1[C:4](=[O:28])[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=C(N3CCCC3)N=[C:14]([N:23]3[CH2:27][CH2:26]CC3)[N:13]=2)[CH2:8][CH2:7]1.CS(O)(=O)=O.[CH3:52][C@@H:53]1C[C@@H]2[C@](C)(CC=C3[C@H]2CCC2[C@]3(C)C=CC(=O)C=2)[C@H]1C(=O)CN1CCN(C2C=C(N3CCCC3)N=C(N3CCCC3)N=2)CC1.CS(O)(=O)=O.CS(O)(=O)=O.C[C@@H]1C[C@@H]2[C@](C)(CC=C3[C@H]2CCC2[C@]3(C)C=CC(=O)C=2)[C@H]1C(=O)CN1CCN(C2C=C(N3CCCC3)N=C(N3CCCC3)N=2)CC1.Cl.C[C@@H]1C[C@@H]2[C@](C)(CC=C3[C@H]2CCC2[C@]3(C)C=CC(=O)C=2)[C@H]1C(=O)CN1CCN(C2C=C(N3CCCC3)N=C(N3CCCC3)N=2)CC1>>[CH2:27]([NH:23][C:14]1[N:13]=[C:12]([N:9]2[CH2:8][CH2:7][N:6]([CH2:5][C:4](=[O:28])[C@@H:3]3[C@:29]4([CH3:46])[C@H:42]([C@H:41]5[C:32](=[CH:31][CH2:30]4)[C@:33]4([CH3:45])[C:38](=[CH:37][C:36](=[O:44])[CH:35]=[CH:34]4)[CH2:39][CH2:40]5)[CH2:43][C@H:2]3[CH3:1])[CH2:11][CH2:10]2)[CH:17]=[CH:53][CH:52]=1)[CH3:26]

参加物

反応物 4

HCID 104902Tirilazad Mesylate2 回

HCID 104903Tirilazad

HCID 18649329HCID 18649329、化合物

HCID 67766221HCID 67766221、化合物

生成物 1

HCID 14307852HCID 14307852、化合物

実験手順

The preferred amino substituted steroid (XI) is 16α-methyl-21-[4[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl]pregna-1,4,9(11)-triene-3,20-dione. More preferred is 16α-methyl-21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl]pregna1,4,9(11)-triene-3,20-dione monomethanesulfonate, 16α-methyl-21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl]pregna1,4,9(11)-triene-3,20-dione bismethanesulfonate and 16α-methyl-21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl]pregna-1,4,9(11)-triene-3,20-dione hydrochloride. Most preferred is 16α-methyl-21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl]pregna-1,4,9(11)-triene-3,20-dione monomethanesulfonate.