Benzimidazole → 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-benzimidazole

HRID 1769611

反応式

HRID 1769611 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:8][CH2:7]1.[N:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[NH:20][CH:19]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[N:13]1[CH:14]=[CH:15][CH:16]=[N:17][C:12]=1[N:9]1[CH2:10][CH2:11][N:6]([CH2:5][CH2:4][CH2:3][CH2:2][N:18]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[N:20]=[CH:19]2)[CH2:7][CH2:8]1

参加物

5

反応物 3

HCID 5798BenzimidazoleHCID 11430Potassium CarbonateHCID 147268432-(4-(4-Bromobutyl)piperazin-1-yl)pyrimidine

生成物 1

HCID 98191481-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-benzimidazole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 6 g (20 mmol) of 2-[4-(4-bromobutyl)-1-piperazinyl]-pyrimidine, 2.36 g (20 mmol) of benzimidazole and 4.1 g (30 mmol) of potassium carbonate in 60 ml of dimethylformamide is refluxed for 14 hours. The reaction mixture is evaporated under vacuum, chloroform is added, the mixture is washed with water, dried over sodium sulphate and evaporated under vacuum and 4.8 g of 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]-butyl}-1H-benzimidazole are obtained, which may be recrystallised from ethyl ether, with a melting point of 85°-88° C.

後処理

  1. temperatureis refluxed for 14 hours
  2. customThe reaction mixture is evaporated under vacuum, chloroform
  3. additionis added
  4. washthe mixture is washed with water
  5. dry with materialdried over sodium sulphate
  6. customevaporated under vacuum and 4.8 g of 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]-butyl}-1H-benzimidazole
  7. customare obtained
  8. customwhich may be recrystallised from ethyl ether, with a melting point of 85°-88° C.

出典と根拠

ORDレコード
ord-bb9f9015a0814603b73a671f894d6868
出典データセット
uspto-grants-1995_01
特許番号
US05382586

関連ノート

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