Hydride → 4-(2-methyl-1,3-thiazol-4-yl)benzaldehyde

HRID 1769665ノート

反応式

HRID 1769665 の反応式
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#N)=[CH:9][CH:8]=2)[N:6]=1.[H-].O.O.S([O-])([O-])(=O)=[O:19].[Na+].[Na+]>C1C=CC=CC=1.C1(C)C=CC=CC=1>[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:14]=[CH:13][C:10]([CH:11]=[O:19])=[CH:9][CH:8]=2)[N:6]=1

参加物

6

反応物 3

HCID 166653HydrideHCID 7163534-(2-Methyl-1,3-thiazol-4-yl)benzonitrileHCID 21438585HCID 21438585、化合物

生成物 1

HCID 8209764-(2-methyl-1,3-thiazol-4-yl)benzaldehyde収率 68%

試薬・触媒・溶媒 2

HCID 241Benzene溶媒HCID 1140Toluene溶媒

実験手順

2.95 g of 4-(2-methyl-1,3-thiazol-4-yl)benznitrile was dissloved in 100 ml of benzene and thereto was added dropwise a solution in toluene (1.5M) of diisobutylalminum hydride at the room temperature. Agitation was made for 1 hour. An excess amount of sodium sulfate dihydrate was added to the mixture and the resultant was stirred at the room temperature. A filtrate liquid thereof was concentrated and purified with column chromatography using silica gel and dichloromethane to obtain 1.95 g of the intended compound with a yield of 68%.

後処理

  1. concentrationA filtrate liquid thereof was concentrated
  2. custompurified with column chromatography

出典と根拠

ORDレコード
ord-4e8ef77915c048c59808471430c4fe32
出典データセット
uspto-grants-1995_01
特許番号
US05382595

反応ノート

読み込み中…