Sodium Cyanide → 3,3-Dicyclopropylpropionitrile
反応式
S(O[CH2:12][CH:13]([CH:17]1[CH2:19][CH2:18]1)[CH:14]1[CH2:16][CH2:15]1)(C1C=CC(C)=CC=1)(=O)=O.[C-:20]#[N:21].[Na+]>CS(C)=O>[CH:17]1([CH:13]([CH:14]2[CH2:15][CH2:16]2)[CH2:12][C:20]#[N:21])[CH2:18][CH2:19]1参加物
4
反応条件
- 温度
- 95 °C
実験手順
209 g of 2,2-dicyclopropylethanol tosylate (prepared from 2,2-dicyclopropylethanol and para-toluenesulfonyl chloride) in solution in 45 ml of DMSO, are slowly added to 40 g of sodium cyanide in 45 ml of dimethyl sulfoxide (DMSO), with stirring and at 95° C. The heating is continued for one hour. After filtration of the precipitate and washing with ethyl ether, the filtrates are pooled, washed with a saturated solution of sodium chloride, dried and evaporated. The expected product is obtained after distillation under vacuum.
後処理
- filtrationAfter filtration of the precipitate
- washwashing with ethyl ether
- washwashed with a saturated solution of sodium chloride
- customdried
- customevaporated
出典と根拠
- ORDレコード
- ord-3a39379e127243d0897ff55a79074e8b
- 出典データセット
- uspto-grants-1995_01
- 特許番号
- US05384322
反応ノート
読み込み中…