3,5-Bis(tert-butyldimethylsilyloxy)benzaldehyde → Ethyl 2-(3,5-bis(tert-butyldimethylsilyloxy)benzylamino)-2-methylpropanoate

HRID 1770595ノート

反応式

HRID 1770595 の反応式
[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([O:17][Si:18]([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19])[CH:16]=1)[CH:12]=O)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Cl.[NH2:26][C:27]([CH3:34])([CH3:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29]>>[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([O:17][Si:18]([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:19])[CH3:20])[CH:16]=1)[CH2:12][NH:26][C:27]([CH3:34])([CH3:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29])([C:4]([CH3:6])([CH3:5])[CH3:7])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 109155453,5-Bis(tert-butyldimethylsilyloxy)benzaldehydeHCID 22343822Ethyl 2-amino-2-methylpropanoate hydrochloride

生成物 1

HCID 59524418Ethyl 2-(3,5-bis(tert-butyldimethylsilyloxy)benzylamino)-2-methylpropanoate収率 88%

実験手順

Prepared as in Example 12-1b from 3,5-bis(tert-butyldimethylsilyloxy)benzaldehyde (Example 12-3c) and ethyl 2-amino-2-methylpropanoate hydrochloride. Yield 88%, colorless liquid. MS 482 (MH+).

出典と根拠

ORDレコード
ord-c677b756e4f94380aa17367fcee6418b
出典データセット
uspto-grants-2016_02
特許番号
US09247759B2

反応ノート

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